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(2010) reported that JNK inhibitors attenuated morphine-induced acute short-term analgesic tolerance but not the fentanyl-induced short-term tolerance (the latter was sensitive to GRK3 knockout)

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Frontiers in Psychiatry, 3 , 118

This process involves two major human proteases: the TMPRSS2 in plasma membrane and cathepsin-L (CTSL) in the endo-lysosome 74